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(S)-Deoxy-thalidomide

E3 Ubiquitin Ligase Ligand

(S)-Deoxy-thalidomide functions as a ligand for E3 ubiquitin ligases, facilitating targeted protein degradation. When conjugated to a target protein via a linker, it forms PROTAC K-Ras Degrader-3, which specifically degrades KRAS mutant proteins. This compound is valuable for research applications in cancer therapeutics, particularly in studies aiming to modulate pathways involving KRAS mutations.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	107657-57-8
Applications	E3 Ubiquitin Ligase Ligand
Formula	C₁₃H₁₂N₂O₃
Molecular Weight	244.25
SMILES	O=C(CC1)NC([C@H]1N2C(C3=CC=CC=C3C2)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.