CRBN ligand-895

Catalog No.: A80645
E3 Ligase Ligand
CRBN ligand-895 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN), facilitating the recruitment of this crucial protein. This compound serves as a valuable building block for the synthesis of PROTACs, including PROTAC HDAC8 Degrader-4. Its application extends to the study of protein degradation pathways and the development of innovative therapeutic strategies in various disease models.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionCRBN ligand-895 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN), facilitating the recruitment of this crucial protein. This compound serves as a valuable building block for the synthesis of PROTACs, including PROTAC HDAC8 Degrader-4. Its application extends to the study of protein degradation pathways and the development of innovative therapeutic strategies in various disease models.
Product Information
Catalog NumA80645
FormulaC17H21NO5
Molecular Weight319.35
CAS Number2782024-56-8
SMILESO=C(C(CC1)C2=CC=C(C=C2)OCC(OC(C)(C)C)=O)NC1=O
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