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E3 ligase Ligand 27

E3 ligase Ligand

E3 ligase Ligand 27 is a selective ligand targeting E3 ubiquitin ligases, facilitating the development of targeted protein degradation technologies. This compound is primarily utilized in the synthesis of the PROTAC BcI-2/BcI-xI Degrader-1, promoting the degradation of specific oncogenic proteins. Its application in research supports the investigation of novel therapeutic strategies in cancer treatment through the modulation of protein homeostasis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	3034204-25-3
Applications	E3 ligase Ligand
Formula	C₂₈H₃₈N₄O₆S
Molecular Weight	558.69
SMILES	O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)CCO4)C4=C2)=O)[C@H](C(C)(C)C)NC(OC(C)(C)C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.