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4-(1E)-2-Nitroethenylbenzoic acid

Ligands for E3 Ligase

4-[(1E)-2-Nitroethenyl]benzoic acid is a specific ligand for E3 ligase, which plays a crucial role in ubiquitination and protein degradation. This compound facilitates the synthesis of PROTAC BRD4 Degrader-38, enabling targeted degradation of specific proteins within cellular pathways. Its application in protein targeting and degradation makes it a valuable tool for researchers investigating proteostasis and related therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	821797-33-5
Applications	Ligands for E3 Ligase
Formula	C₉H₇NO₄
Molecular Weight	193.16
SMILES	OC(C1=CC=C(C=C1)/C=C/[N+]([O-])=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.