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(S,S,S)-VH032-cyclopropane-F

Ligands for E3 Ligase

(S,S,S)-VH032-cyclopropane-F is a ligand that targets E3 ubiquitin ligases, facilitating the selective degradation of specific proteins through the ubiquitin-proteasome system. This compound can be conjugated to target protein ligands using a linker to generate PROTAC derivatives, such as cis-VZ185, which are valuable tools for studying protein dynamics and cellular functions. Its unique mechanism provides opportunities for innovative research in targeted protein degradation and therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2306193-95-1
Applications	Ligands for E3 Ligase
Formula	C₂₆H₃₃FN₄O₅S
Molecular Weight	532.63
SMILES	OC1=C(CNC([C@H]2N(C([C@@H](NC(C3(F)CC3)=O)C(C)(C)C)=O)C[C@@H](O)C2)=O)C=CC(C4=C(N=CS4)C)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.