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BCL-xL/BCL-2 ligand 1

BCL-xL/BCL-2 Ligand

BCL-xL/BCL-2 Ligand 1 is a selective ligand targeting BCL-xL and BCL-2 proteins. This compound serves as a crucial component in the development of PROTACs (proteolysis-targeting chimeras), which promote targeted degradation of specific proteins through E3 ligase recruitment. It is valuable for research focused on apoptosis, cancer biology, and therapeutic development aimed at modulating cell survival pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2941091-91-2
Applications	BCL-xL/BCL-2 Ligand
Formula	C₄₈H₅₃ClF₃N₅O₇S₃
Molecular Weight	1000.61
SMILES	O=C[C@@](C)(C1)CCC(C2=CC=C(C=C2)Cl)=C1CN3CCN(C4=CC=C(C=C4)C(NS(=O)(C5=CC(S(C(F)(F)F)(=O)=O)=C(C=C5)N[C@@H](CSC6=CC=CC=C6)CCN7[C@]8([H])C[C@](OC8)([H])C7)=O)=O)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.