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CRBN ligand-190

Ligands for E3 Ligase

CRBN ligand-190 is a ligand for the CRBN-type E3 ubiquitin ligase, facilitating the targeted ubiquitination and degradation of proteins. This compound is instrumental in the development of PROTACs (proteolysis-targeting chimeras), notably for synthesizing PROTAC HPK1 Degrader-7. Its utility in protein degradation strategies makes it a valuable tool for research in targeted therapy and protein homeostasis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	1543013-96-2
Applications	Ligands for E3 Ligase
Formula	C₁₀H₉FN₂O₂
Molecular Weight	208.19
SMILES	FC1=CC(N(C(N2)=O)CCC2=O)=CC=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.