Fig. 1 · Structure
Documents & Downloads
Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride
Ligands for E3 Ligase
Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride is a ligand that targets the E3 ubiquitin ligase cereblon (CRBN). This compound is designed to facilitate the recruitment of cereblon protein for targeted protein degradation. Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride can be utilized in the development of PROTACs by linking to other protein ligands, enabling innovative research in protein homeostasis and disease modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2758431-94-4 |
| Applications | Ligands for E3 Ligase |
| Formula | C23H30Cl2FN5O4 |
| Molecular Weight | 530.42 |
| SMILES | O=C1NC(C(CC1)N2C(C3=CC(F)=C(N4CCN(CC5CCNCC5)CC4)C=C3C2=O)=O)=O.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.