Fig. 1 · Structure
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(S)-(S,R,S,R)-AHPC-Me-N3
E3 ligase ligand
(S)-(S,R,S,R)-AHPC-Me-N3 is an E3 ligase ligand that facilitates targeted protein degradation through the synthesis of PROTAC molecules. It plays a crucial role in the development of PROTAC SMARCA2 degrader-32, enabling precise modulation of protein levels in cellular systems. This compound is valuable for researchers focused on protein degradation therapies and E3 ligase research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2958620-43-2 |
| Applications | E3 ligase ligand |
| Formula | C23H30N6O3S |
| Molecular Weight | 470.59 |
| SMILES | O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)N=[N+]=[N-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.