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VHL Ligand 36

Ligands for E3 Ligase

VHL Ligand 36 is a selective ligand for the von Hippel-Lindau (VHL) E3 ligase, facilitating targeted ubiquitination of substrate proteins. This compound is instrumental in research applications focused on studying the VHL pathway and its implications in various cellular processes, including tumorigenesis and hypoxia response. Additionally, VHL Ligand 36 serves as a precursor for synthesizing SD-2301, expanding its utility in chemical biology investigations.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2250056-48-3
Applications	Ligands for E3 Ligase
Formula	C₂₃H₃₁N₃O₄S
Molecular Weight	445.57
SMILES	CC(C)(C)[C@H](O)C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.