17-DMAG HCl (Alvespimycin)

17-DMAG is a water-soluble analog of 17-AAG and geldanamycin that binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG.
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Product Name Price Stock Qty
17-DMAG HCl 25mg
$100.00
In stock
17-DMAG HCl 50mg
$180.00
In stock
17-DMAG HCl 100mg
$270.00
In stock
17-DMAG HCl 200mg
$420.00
In stock
17-DMAG HCl (Alvespimycin) 10mM * 1mL in DMSO
$85.00
In stock
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Adooq Products cited in reputable paper
Adooq's 17-DMAG HCl (Alvespimycin) has been cited by 2 publications
  • Yool Lee, .et al. , Sci Adv, 2021, 7
  • Naoki Shiraishi, .et al. , Oncol Rep, 2020, 448-458 PMID: 33416122
  • Biological Activity
    Discription 17-DMAG is a water-soluble analog of 17-AAG and geldanamycin that binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG.
    Targets
    Target Value
    Product Information
    Catalog Num A10011
    Formula C32H48N4O8.HCl
    Molecular Weight 653.2
    CAS Number 467214-21-7
    SMILES CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC.Cl
    Synonyms NSC 707545
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 127 mg/mL (194.42 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 15.31 mL 76.55 mL 153.09 mL
    0.5 mM 3.06 mL 15.31 mL 30.62 mL
    1 mM 1.53 mL 7.65 mL 15.31 mL
    5 mM 0.31 mL 1.53 mL 3.06 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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