Fig. 1 · Structure

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3,4-Dihydroxybenzaldehyde

Cat. No. A14824 CAS 139-85-5
3,4-Dihydroxybenzaldehyde, protocatechuic aldehyde induces apoptosis of human leukemia cells, as well as malignant HSG1 cells taken from human oral cavities.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
A549 IC50 > 10 μM Cytotoxicity against human A549 cells after 48 hrs by MTT assay [PMID: 25710081]
A549 IC50 3.1 μM Cytotoxicity against human A549 cells after 4 days by MTT assay [PMID: 24359303]
A549 GI50 42 μM Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay [PMID: 25752525]
B16-4A5 IC50 17 μM Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells after 72 hrs [PMID: 20189399]
Bel-7402 IC50 3.7 μM Cytotoxicity against human Bel7402 cells after 4 days by MTT assay [PMID: 24359303]
BMDM IC50 15 μM Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-base [PMID: 31257875]
BV-2 IC50 > 100 μM Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay [PMID: 28911817]
DLD-1 IC50 70 μM Cytotoxicity against human DLD1 cells after 96 hrs by MTT assay [PMID: 15387639]
HBL-100 GI50 > 100 μM Antiproliferative activity against human HBL100 cells after 48 hrs by sulforhodamine B assay [PMID: 25752525]
HeLa GI50 49 μM Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay [PMID: 25752525]
HepG2 2.2.15 EC50 2.46 μg/mL Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV e antigen secretion by ELISA [PMID: 24549242]
HepG2 2.2.15 EC50 3.94 μg/mL Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV surface antigen secretion by ELISA [PMID: 24549242]
HepG2 2.2.15 IC50 4.17 μg/mL Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV DNA production by quantitative RT-PCR analysis [PMID: 24549242]
K562 IC50 > 10 μM Cytotoxicity against human K562 cells after 48 hrs by MTT assay [PMID: 25710081]
KB IC50 > 10 μM Cytotoxicity against human KB cells after 4 days by MTT assay [PMID: 24359303]
N9 IC50 > 100 μM Antineuroinflammatory activity in mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay [PMID: 28073678]
SW1573 GI50 54 μM Antiproliferative activity against human SW1573 cells after 48 hrs by sulforhodamine B assay [PMID: 25752525]
T47D GI50 > 100 μM Antiproliferative activity against human T47D cells after 48 hrs by sulforhodamine B assay [PMID: 25752525]
WiDr GI50 > 100 μM Antiproliferative activity against human WiDr cells after 48 hrs by sulforhodamine B assay [PMID: 25752525]

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Specifications

Manufacturer Adooq Bioscience
CAS Number 139-85-5
Formula C7H6O3
Molecular Weight 138.12
Synonyms Protocatechualdehyde
SMILES
C1=CC(=C(C=C1C=O)O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 26 mg/mL (188.24 mM)
Ethanol <1 mg/mL

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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