7ACC1 selectively interfere with lactate fluxes in the lactate-rich tumor microenvironment; inhibits lactate influx but not efflux in tumor cells expressing MCT1 and MCT4 transporters.
Daniel Gundel, .et al. , Int J Mol Sci, 2021, Feb; 22(4): 1645 PMID: 33562048
Biological Activity
Description
7ACC1 selectively interfere with lactate fluxes in the lactate-rich tumor microenvironment; inhibits lactate influx but not efflux in tumor cells expressing MCT1 and MCT4 transporters.
Cell Research
Cell Line
Type
Value
Description
References
Product Information
Catalog Num
A15810
Formula
C14H15NO4
Molecular Weight
261.27
CAS Number
50995-74-9
SMILES
CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)C(=O)O
Synonyms
DEAC, Coumarin D 1421, D 1421
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Solubility
In vitro
DMSO
45 mg/mL (172.23 mM)
Water
Insoluble
Ethanol
Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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