ABT-199 (Venetoclax)

ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2.
Grouped product items
Product Name Price Stock Qty
ABT-199 10mg
$75.00
In stock
ABT-199 50mg
$100.00
In stock
ABT-199 100mg
$125.00
In stock
ABT-199 10mM * 1mL in DMSO
$70.00
In stock
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Adooq Products cited in reputable paper
Adooq's ABT-199 (Venetoclax) has been cited by 7 publications
  • Dilay Karademir, .et al. , Med Oncol, 2023, Jul 11;40(8):234 PMID: 37432531
  • Ashlyn Parkhurst, .et al. , Cell Death Dis, 2022, Apr 28;13(4):410 PMID: 35484114
  • Anna L Koessinger, .et al. , Cell Death Differ, 2022, Apr 26 PMID: 35473984
  • Florian J Bock, .et al. , Nat Commun, 2021, Nov 12;12(1):6572 PMID: 34772930
  • Chauhan D, .et al. , Cell Rep, 2018, Nov 27;25(9):2354-2368.e5 PMID: 30485805
  • Martin Grundy, .et al. , PLoS One, 2018, 13(1): e0190682 PMID: 29298347
  • Joanne Dai, .et al. , J Immunol, 2018, 200 (5) 1727-1736 PMID: 29358277
  • Biological Activity
    Discription ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2.
    Targets
    Target Value
    Product Information
    Catalog Num A12500
    Formula C45H50ClN7O7S
    Molecular Weight 868.44
    CAS Number 1257044-40-8
    SMILES CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C
    Synonyms ABT199; ABT 199; GDC-0199; RG7601
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO Warmed: 93 mg/mL (107.08 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 5% DMSO+50% PEG 300+5% Tween 80+ddH2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 11.51 mL 57.57 mL 115.15 mL
    0.5 mM 2.3 mL 11.51 mL 23.03 mL
    1 mM 1.15 mL 5.76 mL 11.51 mL
    5 mM 0.23 mL 1.15 mL 2.3 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

    • Mass

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      Volume

      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

    • C1

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