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EGFR inhibitor
In Stock
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| Target | Activity | Value |
|---|---|---|
| PDGFR | 0.5 μM | |
| EGFR | 460 μM |
| Cell Line | Activity | Value | Description | Reference |
|---|---|---|---|---|
| HCT-116 | IC50 | > 0.2 μM | Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay | [PMID: 29156129] |
| Hepatocyte | IC50 | > 0.97 μM | Cytotoxicity against Sprague-Dawley rat hepatocytes after 24 hrs by MTT assay | [PMID: 29156129] |
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 10537-47-0 |
| Applications | EGFR inhibitor |
| Formula | C18H22N2O |
| Molecular Weight | 282.4 |
| Synonyms | NSC 242557; RG-50872; GCP 5126; SF 6847; Tyrphostin AG-17; Malonoben; Tyrphostin 9; AG-17 |
| SMILES | CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(C#N)C#N |
| Solvent | Reported Solubility |
|---|---|
| DMSO | 51 mg/mL (180.6 mM) |
| Water | Insoluble |
| Ethanol | 51 mg/mL (180.6 mM) |
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
