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Fig. 1 · Structure
Cat. No.
A15399
CAS No.
27013-91-8
Formula
C42H66O12
Mol. Weight
750.96

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alpha-hederin

Cat. No. A15399 CAS 27013-91-8
Alpha-hederin, a saponin extracted from Hedera helix.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
A549 IC50 12.29 μM Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by MTT assay [PMID: 23992864]
A549 IC50 15.3 μM Cytotoxicity against human A549 cells assessed as inhibition of cell growth after 24 hrs by MTT assay [PMID: 25958248]
A549 IC50 28 μM Cell membrane permeabilization in human A549 cells assessed as drug level causing decrease in calcein fluorescence [PMID: 19200744]
A549 IC50 33 μM Cytotoxicity against human A549 cells after 48 hrs by resazurin reduction test [PMID: 19200744]
Bel-7402 IC50 13.2 μM Cytotoxicity against human Bel7402 cells assessed as inhibition of cell growth after 24 hrs by MTT assay [PMID: 25958248]
DLD-1 IC50 38 μM Cell membrane permeabilization in human DLD1 cells assessed as drug level causing decrease in calcein fluorescence [PMID: 19200744]
DLD-1 IC50 60 μM Cytotoxicity against human DLD1 cells after 48 hrs by resazurin reduction test [PMID: 19200744]
ECV-304 IC50 29 μM Membrane toxicity against human ECV304 cells after 2 hrs by LDH release assay [PMID: 24084294]
ECV-304 IC50 29 μM Membranolytic activity in human ECV304 cells assessed as leakage of intracellular lactate dehydrogenase after 2 hrs by spectrophotometry [PMID: 22503361]
ECV-304 IC50 35 μM Cytotoxicity against human ECV304 cells after 72 hrs by Hoechst 33258 staining based fluorescence assay [PMID: 22503361]
ECV-304 IC50 35 μM Cytotoxicity against human ECV304 cells after 72 hrs by MTT assay [PMID: 24084294]
HeLa IC50 21.18 μM Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay [PMID: 23992864]
HepG2 IC50 16.34 μM Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay [PMID: 23992864]
HepG2 IC50 5.5 μM Inhibition of TNF-alpha-induced NFkappaB activation in human HepG2 cells after 1 hr by luciferase reporter assay [PMID: 21870831]
HL-60 IC50 11.78 μM Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by MTT assay [PMID: 23992864]
HL-60 IC50 7.1 μg/mL Cytotoxicity against human HL-60 cells after 72 hrs by MTT assay [PMID: 10514313]
HL-60 IC50 7.1 μg/mL Cytotoxicity against human HL60 cells by MTT assay [PMID: 11575962]
L02 IC50 11.5 μM Cytotoxicity against human HL7702 cells assessed as inhibition of cell growth after 24 hrs by MTT assay [PMID: 25958248]
L02 IC50 20.98 μM Cytotoxicity against human L02 cells by MTT assay [PMID: 33964439]
RAW264.7 IC50 1.1 μM Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitirc oxide production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess assay [PMID: 31301930]

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Specifications

Manufacturer Adooq Bioscience
CAS Number 27013-91-8
Formula C42H66O12
Molecular Weight 750.96
SMILES
C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@H](CO[C@H]2O[C@H]3CC[C@]4([C@H]([C@]3(C)CO)CC[C@@]5([C@@H]4CC=C6[C@]5(CC[C@@]7([C@H]6CC(CC7)(C)C)C(=O)O)C)C)C)O)O)O)O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 95 mg/mL (126.5 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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