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Alvelestat

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neutrophil elastase inhibitor

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Catalog No. A12779

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Alvelestat 5mg A12779-5

Regular Price: $120.00

Special Price: $108.00

Alvelestat 10mg A12779-10

Regular Price: $190.00

Special Price: $171.00

Alvelestat 25mg A12779-25

Regular Price: $350.00

Special Price: $315.00

Alvelestat 10mM * 1mL in DMSO A12779-10mM-D

Regular Price: $223.00

Special Price: $200.70

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Avelestat, also known as AZD9668, is a novel, oral inhibitor of neutrophil elastase (NE).

Alvelestat

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Chemical Information

Catalog Num A12779
Actions Inhibitor
M. Wt 545.5
Formula C25H22F3N5O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 848141-11-7
Synonyms AZD9668,AZD 9668,AZD-9668
SMILES code CC1=C(C=C(C(=O)N1C2=CC=CC(=C2)C(F)(F)F)C(=O)NCC3=NC=C(C=C3)S(=O)(=O)C)C4=CC=NN4C
Chemical Name 6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-((5-(methylsulfonyl)pyridin-2-yl)methyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide

Biological Activity

Description
Avelestat, also known as AZD9668, is a novel, oral inhibitor of neutrophil elastase (NE).
Targets
neutrophil elastase neutrophil elastase
9.4 nM(Ki)12 nM

Solubility

Solubility (25°C)* In vitro DMSO 100 mg/mL (183.3 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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