Cellular Effect
| Cell Line | Activity | Value | Description | Reference |
|---|---|---|---|---|
| CHO | EC50 | 80 nM | Positive allosteric modulation of human CaSR transfected in CHO cells after 5 hrs by luciferase reporter gene assay | [PMID: 23465611] |
Fig. 1 · Structure
Documents & Downloads
Cinacalcet (AMG 073)
Cat. No.
A11314
CAS
226256-56-0
CaSR activator
AMG-073 (Cinacalcet) represents a new class of compounds for the treatment of hyperparathyroidism.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 226256-56-0 |
| Applications | CaSR activator |
| Formula | C22H22F3N |
| Molecular Weight | 357.41 |
| Synonyms | AMG 073 |
| SMILES | C[C@H](C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.