AMG 900

Aurora Kinase inhibitor

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Catalog No. A11066

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AMG 900 5mg A11066-5
$90.00
AMG 900 10mg A11066-10
$160.00
AMG 900 50mg A11066-50
$450.00
AMG 900 100mg A11066-100
$750.00
AMG 900 10mM * 1mL in DMSO A11066-10mM-D
$150.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AMG 900 is a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines.

AMG 900

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Chemical Information

Catalog Num A11066
Actions Inhibitor
M. Wt 503.6
Formula C28H21N7OS
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 945595-80-2
Synonyms AMG-900, AMG900
SMILES code CC1=CSC(=C1)C2=NN=C(C3=CC=CC=C32)NC4=CC=C(C=C4)OC5=C(C=CC=N5)C6=NC(=NC=C6)N
Chemical Name N-[4-[[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine

Biological Activity

Description
AMG 900 is a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines.
Targets
Target Value
AuroraCIC50: 1nM
AuroraBIC50: 4nM
AuroraAIC50: 5nM
p38αIC50: 53nM
TYK2IC50: 220nM
JNK2IC50: 520nM
MetIC50: 550nM
Tie-2IC50: 650nM

Solubility

Solubility (25°C) * In vitro DMSO 100 mg/mL (198.57 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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