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MDM2 inhibitor

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Catalog No. A14394
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Product Name Catalog No. Price
AMG232 5mg A14394-5

Regular Price: $120.00

Special Price: $96.00

AMG232 10mg A14394-10

Regular Price: $200.00

Special Price: $160.00

AMG232 25mg A14394-25

Regular Price: $400.00

Special Price: $320.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AMG 232 is a highly potent, selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction((SPR KD= 0.045 nM, SJSA-1 EdU IC50=9.1 nM).


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Chemical Information

Catalog Num A14394
Actions Inhibitor
M. Wt 568.55
Formula C28H35Cl2NO5S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1352066-68-2
Synonyms AMG-232, AMG 232
SMILES code CC(C)[[email protected]@H](CS(=O)(=O)C(C)C)N1[[email protected]@H]([[email protected]](C[[email protected]](C1=O)(C)CC(=O)O)C2=CC(=CC=C2)Cl)C3=CC=C(C=C3)Cl
Chemical Name 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

Biological Activity

AMG 232 is a highly potent, selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction((SPR KD= 0.045 nM, SJSA-1 EdU IC50=9.1 nM).

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