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ANX-510

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Catalog No. A12370

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
ANX-510 5mg A12370-5

Regular Price: $180.00

Special Price: $144.00

ANX-510 10mg A12370-10

Regular Price: $350.00

Special Price: $280.00

ANX-510 25mg A12370-25

Regular Price: $600.00

Special Price: $480.00

ANX-510 50mg A12370-50

Regular Price: $1,000.00

Special Price: $800.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

ANX-510 is a folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Unlike leucovorin, MTHF, as the active form of folate, does not require metabolic activation and may increase the chemotherapeutic effects of fluorouracil with lower toxicity.

ANX-510

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Chemical Information

Catalog Num A12370
Actions N/A
M. Wt 457.44
Formula C20H23N7O6
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 3432-99-3
Synonyms ANX510; CoFactor; 5,10-methylenetetrahydrofolate; 5,10-Methylene-5,6,7,8-tetrahydrofolate; 5,10-MTHF; MTHF
SMILES code C1C2CN(CN2C3=C(N1)NC(=NC3=O)N)C4=CC=C(C=C4)C(=O)N[[email protected]@H](CCC(=O)O)C(=O)O
Chemical Name (2S)-2-(4-(3-amino-1-oxo-5,6,6a,7-tetrahydroimidazo[1,5-f]pteridin-8(1H,4H,9H)-yl)benzamido)pentanedioic acid

Biological Activity

Description
ANX-510 is a folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Unlike leucovorin, MTHF, as the active form of folate, does not require metabolic activation and may increase the chemotherapeutic effects of fluorouracil with lower toxicity.

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