AR-A 014418

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GSK-3 inhibitor

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Catalog No. A13728

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AR-A 014418 10mg A13728-10

Regular Price: $60.00

Special Price: $51.00

AR-A 014418 25mg A13728-25

Regular Price: $120.00

Special Price: $102.00

AR-A 014418 50mg A13728-50

Regular Price: $200.00

Special Price: $170.00

AR-A 014418 100mg A13728-100

Regular Price: $350.00

Special Price: $297.50

AR-A 014418 10mM * 1mL in DMSO A13728-10mM-D

Regular Price: $60.00

Special Price: $51.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.

AR-A 014418

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Chemical Information

Catalog Num A13728
Actions Inhibitor
M. Wt 308.31
Formula C12H12N4O4S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 487021-52-3
Synonyms AR-A014418, ARA 014418, ARA014418
SMILES code COC1=CC=C(C=C1)CNC(=O)NC2=NC=C(S2)[N+](=O)[O-]
Chemical Name N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea

Biological Activity

Description
AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.
Targets
GSK-3β (Cell-free assay) GSK-3β (Cell-free assay)
38 nM(Ki)38 nM(Ki)

Solubility

Solubility (25°C)* In vitro DMSO 62 mg/mL (201.09 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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