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Ascomycin

Name: Ascomycin
Brand: Adooq Bioscience
SKU: A12592
Availability: InStock

Cat. No. A12592 CAS 104987-12-4

calcineurin inhibitor

Ascomycin is a potent immunosuppressive agent that could be used as a potential therapeutic agent for autoimmune diseases.

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Biological Activity

Target & Activity

Target	Activity	Value
calcineurin phosphatase		49 nM

Cellular Effect

Cell Line	Activity	Value	Description	Reference
Jurkat	IC50	0.205 nM	Inhibition of calcineurin in human Jurkat cells assessed as inhibition of NFAT-mediated IL-2 production after 8 hrs by beta-lactamase reporter gene assay	10.1039/C2MD20266B
T-cell	IC50	0.69 nM	Agonistic activity in a murine splenic T-cell proliferation assay was calculated by measurement of [3H]thymidine uptake relative to control	10.1016/S0960-894X(01)81248-8

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	104987-12-4
Applications	calcineurin inhibitor
Formula	C₄₃H₆₉NO₁₂
Molecular Weight	792.01
Synonyms	FK 520; FR 900520
SMILES	CC[C@@H]1/C=C(/C[C@@H](C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC1=O)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC)C)\C

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	98 mg/mL (123.73 mM)
Water	Insoluble
Ethanol	98 mg/mL (123.73 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.