AT-406 (SM-406, ARRY-334543)

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IAP inhibitor

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Catalog No. A11163

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AT-406 5mg A11163-5
$90.00
AT-406 10mg A11163-10
$160.00
AT-406 50mg A11163-50
$500.00
AT-406 200mg A11163-200
$1,650.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AT-406 is an orally bioavailable inhibitor of IAP family of proteins with potential apoptotic inducing and antineoplastic activity. AT-406 selectively inhibits the biological activity of IAP proteins, including X chromosome-linked IAP (XIAP), the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2) and melanoma inhibitor of apoptosis protein (ML-IAP).

AT-406 (SM-406, ARRY-334543)

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Chemical Information

Catalog Num A11163
Actions Inhibitor
M. Wt 561.71
Formula C32H43N5O4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1071992-99-8
Synonyms AT406, SM-406, ARRY-334543
SMILES code C[C@@H](C(=O)N[[email protected]]1CN(CC[[email protected]]2CC[[email protected]](N2C1=O)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)CC(C)C)NC
Chemical Name (5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide

Biological Activity

Description
AT-406 is an orally bioavailable inhibitor of IAP family of proteins with potential apoptotic inducing and antineoplastic activity. AT-406 selectively inhibits the biological activity of IAP proteins, including X chromosome-linked IAP (XIAP), the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2) and melanoma inhibitor of apoptosis protein (ML-IAP).

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