Xevinapant (AT-406, SM-406, ARRY-334543)

AT-406 is an orally bioavailable inhibitor of IAP family of proteins with potential apoptotic inducing and antineoplastic activity. AT-406 selectively inhibits the biological activity of IAP proteins, including X chromosome-linked IAP (XIAP), the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2) and melanoma inhibitor of apoptosis protein (ML-IAP).
Grouped product items
Product Name Price Stock Qty
AT-406 5mg
$120.00
In stock
AT-406 10mg
$160.00
In stock
AT-406 50mg
$620.00
In stock
AT-406 200mg
$1,980.00
In stock
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Adooq Products cited in reputable paper
Adooq's Xevinapant (AT-406, SM-406, ARRY-334543) has been cited by 2 publications
  • Yoshikawa M, .et al. , J Med Chem, 2018, Mar 22;61(6):2384-2409 PMID: 29485864
  • Tsuyoshi Ishii, .et al. , Sci Rep, 2017, 7: 13000 PMID: 29026104
  • Biological Activity
    Discription AT-406 is an orally bioavailable inhibitor of IAP family of proteins with potential apoptotic inducing and antineoplastic activity. AT-406 selectively inhibits the biological activity of IAP proteins, including X chromosome-linked IAP (XIAP), the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2) and melanoma inhibitor of apoptosis protein (ML-IAP).
    Targets
    Target Value
    Product Information
    Catalog Num A11163
    Formula C32H43N5O4
    Molecular Weight 561.71
    CAS Number 1071992-99-8
    SMILES C[C@@H](C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)CC(C)C)NC
    Synonyms AT406, SM-406, ARRY-334543
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 85 mg/mL (151.32 mM)
    Water Insoluble
    Ethanol 85 mg/mL (151.32 mM)
    In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 17.8 mL 89.01 mL 178.03 mL
    0.5 mM 3.56 mL 17.8 mL 35.61 mL
    1 mM 1.78 mL 8.9 mL 17.8 mL
    5 mM 0.36 mL 1.78 mL 3.56 mL
    Useful Calculator

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    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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