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AT7519 HCl

Name: AT7519 HCl
Brand: Adooq Bioscience
SKU: A11313
Availability: InStock

Cat. No. A11313 CAS 902135-91-5

CDK inhibitor

AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation.

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Biological Activity

Target & Activity

Target	Activity	Value
CDK9/CyclinT	IC50	<10nM
CDK5/p35	IC50	13nM
CDK2/CyclinA	IC50	47nM
GSK-3β	IC50	89nM
CDK4/CyclinD1	IC50	100nM
CDK6/CyclinD3	IC50	170nM
CDK1/CyclinB	IC50	210nM
CDK3/CyclinE	IC50	360nM
PI3Kβ	IC50	>1μM
PLK3	IC50	>1μM
RET	IC50	>1μM
SGK	IC50	>1μM
TrkB	IC50	>1μM
JAK2	IC50	>1μM
CDK7/CyclinH/MAT1	IC50	2.4μM
SAPK2A(p38α)	IC50	>10μM
p70S6K	IC50	>10μM
PDGFR	IC50	>10μM
PDK-1	IC50	>10μM
PKBβ	IC50	>10μM
VEGFR1	IC50	>10μM
AuroraA	IC50	>10μM
c-Abl	IC50	>10μM
c-Src	IC50	>10μM
Chk1	IC50	>10μM
EGFR	IC50	>10μM
FGFR3	IC50	>10μM
IR	IC50	>10μM
JNK2	IC50	>10μM
MAPK1	IC50	>10μM
MEK1	IC50	>10μM
Met	IC50	>10μM

32 targets · Scroll to view more

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	902135-91-5
Applications	CDK inhibitor
Formula	C₁₆H₁₇Cl₂N₅O₂.HCl
Molecular Weight	418.7
Synonyms	AT 7519
SMILES	C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	Warmed: 49 mg/mL (117.03 mM)
Water	Warmed: 40 mg/mL (95.53 mM)
Ethanol	Warmed: 26 mg/mL (62.09 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

In Vivo Preparation

Concentration: 28 mg/mL
Vehicle: Saline

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.