Fig. 1 · Structure

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AT7519 trifluoroacetate

Cat. No. A15005 CAS 1431697-85-6

CDK inhibitor

AT7519 trifluoroacetate is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM, less potent to CDK3 and little active to CDK7.

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Biological Activity

Target & Activity

Target Activity Value
CDK9/Cyclin T IC50 10 nM
CDK5/p35 IC50 13 nM
cdk2/cyclin A IC50 47 nM
Cdk4/cyclin D1 IC50 100 nM
cdk6/cyclin D3 IC50 170 nM
Cdk1/cyclin B IC50 210 nM
CDK7/Cyclin H/MAT1 IC50 2400 nM
GSK3β IC50 89 nM

8 targets · Scroll to view more

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 1431697-85-6
Applications CDK inhibitor
Formula C18H18Cl2F3N5O4
Molecular Weight 496.27
SMILES
C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl.C(=O)(C(F)(F)F)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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