AUY922 (NVP-AUY922) ON SALE HSP90 Inhibitor

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Catalog No. A10659

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AUY922 5mg A10659-5

Regular Price: $40.00

Special Price: $34.00

AUY922 10mg A10659-10

Regular Price: $70.00

Special Price: $59.50

AUY922 25mg A10659-25

Regular Price: $140.00

Special Price: $119.00

AUY922 100mg A10659-100

Regular Price: $400.00

Special Price: $340.00

AUY922 (NVP-AUY922) 10mM * 1mL in DMSO A10659-10mM-D

Regular Price: $96.00

Special Price: $81.60

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AUY922 (NVP-AUY922) is highly potent and oral inhibitor of Hsp90 with IC50=21 nM in Hsp90 FP binding assay and inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM.

AUY922 (NVP-AUY922)

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Chemical Information

Catalog Num A10659
Actions Inhibitor
M. Wt 465.5
Formula C26H31N3O5
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 747412-49-3
Synonyms VER-52296, AUY-922
SMILES code CCNC(=O)C1=C(/C(=C/2\C=C(C(=CC2=O)O)C(C)C)/ON1)C3=CC=C(C=C3)CN4CCOCC4
Chemical Name 5-(2,4-Dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide

Biological Activity

Description
AUY922 (NVP-AUY922) is highly potent and oral inhibitor of Hsp90 with IC50=21 nM in Hsp90 FP binding assay and inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM.
Targets
HSP90α (Cell-free assay) HSP90β (Cell-free assay)
13 nM21 nM

Solubility

Solubility (25°C) * In vitro DMSO 93 mg/mL heating (199.76 mM)
Water <1 mg/mL (<1 mM)
Ethanol 31 mg/mL (66.58 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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