AZ5104

EGFR inhibitor

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Catalog No. A15516

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AZ5104 10mg A15516-10
$80.00
AZ5104 25mg A15516-25
$160.00
AZ5104 50mg A15516-50
$278.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.

AZ5104

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Chemical Information

Catalog Num A15516
Actions Inhibitor
M. Wt 485.58
Formula C27H31N7O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1421373-98-9
Synonyms AZ-5104, AZ 5104
SMILES code CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CNC4=CC=CC=C43)OC
Chemical Name (Z)-N-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylimidic acid

Biological Activity

Description
AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.
Targets
Target Value
EGFR(L858R/T790M)IC50: <1nM
EGFR(L861Q)IC50: 1nM
EGFR(L858R)IC50: 6nM
ErbB4IC50: 7nM
EGFR(wildtype)IC50: 25nM
ACK1IC50: 27nM
BLKIC50: 27nM
BRKIC50: 45nM
MNK2IC50: 62nM
IGF1-RIC50: 78nM
ALKIC50: 97nM
TECIC50: 118nM
FESIC50: 127nM
InsRIC50: 127nM
FLT3IC50: 129nM
BTKIC50: 132nM
FAKIC50: 136nM
MLK1IC50: 141nM
FLT4IC50: 142nM
PYK2IC50: 284nM
IRRIC50: 423nM
TxkIC50: 426nM
BMXIC50: 505nM
ITKIC50: 925nM
JAK3IC50: 1358nM

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