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Fig. 1 · Structure
Cat. No.
A11999
CAS No.
472-15-1
Formula
C30H48O3
Mol. Weight
456.7

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Betulinic acid

Cat. No. A11999 CAS 472-15-1
Betulinic acid is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties.

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Biological Activity

Target & Activity

Target Activity Value
HIV-1 EC50 1.4 μM
Eukaryotic topoisomerase I 5 μM
Aminopeptidase N 7.3 μM

Cellular Effect

Cell Line Activity Value Description Reference
4T1 IC50 14.04 μM Cytotoxicity against mouse 4T1 cells assessed as growth inhibition after 96 hrs by SRB assay [PMID: 25817774]
518A2 IC50 0.33 μM Antitumor activity against human 518A2 cells by SRB assay [PMID: 31499360]
518A2 EC50 11.9 μM Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay [PMID: 27142753]
518A2 IC50 11.9 μM Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay [PMID: 24161703]
518A2 IC50 11.9 μM Cytotoxicity against human 518A2 cells assessed as cell viability after 96 hrs by SRB assay [PMID: 23245801]
518A2 IC50 11.9 μM Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay [PMID: 20034802]
518A2 EC50 11.9 μM Anticancer activity against human 518A2 cells measured after 96 hrs by sulforhodamine B assay [PMID: 31330447]
518A2 EC50 11.9 μM Cytotoxicity against human 518A2 cells after 96 hrs by sulforhodamine B assay [PMID: 26211461]
518A2 IC50 11.9 μM Cytotoxicity against human 518A2 cells after 96 hrs by sulforhodamine B assay [PMID: 20846866]
518A2 IC50 11.9 μM Cytotoxicity against human 518A2 cells after 96 hrs by sulforhodamine B assay [PMID: 20299226]
518A2 EC50 13.6 μM Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay [PMID: 28169163]
518A2 IC50 14.8 μM Cytotoxicity against human 518A2 cells assessed as cell viability after 96 hrs by SRB assay [PMID: 23973824]
518A2 IC50 8.13 μM Cytotoxicity against human 518A2 cells after 96 hrs by SRB colorimetric assay [PMID: 20472329]
518A2 IC50 8.13 μM Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay [PMID: 20451375]
518A2 EC50 9.4 μM Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay [PMID: 28033541]
518A2 EC50 9.4 μM Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay [PMID: 27017553]
518A2 EC50 9.4 μM Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay [PMID: 26750249]
518A2 EC50 9.4 μM Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay [PMID: 26547057]
518A2 EC50 9.4 μM Cytotoxicity against human 518A2 cells after 96 hrs by sulforhodamine B assay [PMID: 30278332]
518A2 EC50 9.4 μM Cytotoxicity against human 518A2 cells assessed as reduction in cell proliferation after 96 hrs by sulforhodamine B assay [PMID: 27149037]
8505C IC50 0.33 μM Antitumor activity against human 8505C cells by SRB assay [PMID: 31499360]

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Specifications

Manufacturer Adooq Bioscience
CAS Number 472-15-1
Formula C30H48O3
Molecular Weight 456.7
SMILES
CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)C(=O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 17 mg/mL (37.22 mM)
Water Insoluble
Ethanol 9 mg/mL (19.7 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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