Target & Activity
| Target | Activity | Value |
|---|---|---|
| EGFR | IC50 | 5 nM |
| HER2 | IC50 | 20 nM |
| HER4 | IC50 | 60 nM |
Fig. 1 · Structure
Documents & Downloads
BMS-690514
Cat. No.
A11263
CAS
859853-30-8
VEGFR/EGFR Inhibitor
BMS-690514 is a potent and selective inhibitor of epidermal growth factor receptor (EGFR), HER2, and HER4, as well as the VEGF receptor kinases.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 859853-30-8 |
| Applications | VEGFR/EGFR Inhibitor |
| Formula | C19H24N6O2 |
| Molecular Weight | 368.4 |
| SMILES | COC1=CC=CC(=C1)NC2=NC=NN3C2=C(C=C3)CN4CC[C@H]([C@@H](C4)O)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.