Brivanib alaninate (BMS-582664)

VEGFR inhibitor

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Catalog No. A10162

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Brivanib alaninate 5mg A10162-5
$90.00
Brivanib alaninate 10mg A10162-10
$168.00
Brivanib alaninate 25mg A10162-25
$368.00
Brivanib alaninate 50mg A10162-50
$688.00
Brivanib alaninate 10mM * 1mL in DMSO A10162-10mM-D
$138.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Brivanib alaninate (BMS-582664) is a dual tyrosine kinase inhibitor of VEGFR and FGFR signaling.

Brivanib alaninate (BMS-582664)

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Chemical Information

Catalog Num A10162
Actions Inhibitor
M. Wt 441.5
Formula C22H24FN5O4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 649735-63-7
Synonyms BMS582664
SMILES code CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NN4C3=C(C(=C4)OC[[email protected]@H](C)OC(=O)[[email protected]](C)N)C
Chemical Name (S)-(R)-1-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)propan-2-yl 2-aminopropanoate

Biological Activity

Description
Brivanib alaninate (BMS-582664) is a dual tyrosine kinase inhibitor of VEGFR and FGFR signaling.
Targets
VEGFR2 Flk1 FGFR1 VEGFR1
25 nM89 nM148 nM380 nM

Solubility

Solubility (25°C) * In vitro DMSO 88 mg/mL (199.33 mM)
Water <1 mg/mL (<1 mM)
Ethanol 88 mg/mL (199.33 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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