Brivanib (BMS-540215)

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VEGFR-2 inhibitor

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Catalog No. A10254

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Brivanib 5mg A10254-5
$90.00
Brivanib 10mg A10254-10
$160.00
Brivanib 50mg A10254-50
$450.00
Brivanib 200mg A10254-200
$1,200.00
Brivanib (BMS-540215) 10mM * 1mL in DMSO A10254-10mM-D
$126.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Brivanib (BMS-540215) is a VEGFR -2 inhibitor with an IC50 of 25 nM and Ki of 26 nM.

Brivanib (BMS-540215)

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Chemical Information

Catalog Num A10254
Actions Inhibitor
M. Wt 370.4
Formula C19H19FN4O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 649735-46-6
Synonyms BMS540215
SMILES code CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NN4C3=C(C(=C4)OC[C@@H](C)O)C
Chemical Name (R)-1-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)propan-2-ol

Biological Activity

Description
Brivanib (BMS-540215) is a VEGFR -2 inhibitor with an IC50 of 25 nM and Ki of 26 nM.
Targets
Target Value
VEGFR2IC50: 25nM
Flk1IC50: 89nM
FGFR1IC50: 148nM
VEGFR1IC50: 380nM
EGFRIC50: >1.9μM
LCKIC50: >2.5μM
PDGFRβIC50: >6μM
PKCαIC50: >25μM
JAK3IC50: >50μM

Solubility

Solubility (25°C)* In vitro DMSO 74 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (8.09 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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