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CC-115

Name: CC-115
Brand: Adooq Bioscience
SKU: A15779
Availability: InStock

Cat. No. A15779 CAS 1228013-15-7

mTOR/DNA-PK inhibitor

CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).

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Biological Activity

Target & Activity

Target	Activity	Value
DNA-PK	IC50	13 nM
mTOR	IC50	21 nM
mTORC1
mTORC2
PI3Kα	IC50	852 nM

Cellular Effect

Cell Line	Activity	Value	Description	Reference
PC-3	IC50	0.022 μM	Inhibition of mTORC2 in human PC3 cells assessed as inhibition of AKT phosphorylation at S473 after 1 hr	[PMID: 26102506]
PC-3	IC50	0.023 μM	Inhibition of mTORC1 in human PC3 cells assessed as inhibition of S6 phosphorylation after 1 hr	[PMID: 26102506]
PC-3	IC50	0.138 μM	Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation after 72 hrs	[PMID: 26102506]

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1228013-15-7
Applications	mTOR/DNA-PK inhibitor
Formula	C₁₆H₁₆N₈O
Molecular Weight	336.35
SMILES	CCN1C(=O)CNC2=NC=C(N=C21)C3=C(N=C(C=C3)C4=NC=NN4)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	61 mg/mL (181.35 mM)
Water	Insoluble
Ethanol	Insoluble

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.