Target & Activity
| Target | Activity | Value |
|---|---|---|
| CCR5 | IC50 | 0.29 nM |
| CCR2 | IC50 | 5.9 nM |
| R5 HIV-1 | 0.024-0.08 nM (IC50, in PBMCs) | |
| R5 HIV-2 | 0.03-0.98 nM (IC50, in PBMCs) |
Fig. 1 · Structure
Documents & Downloads
Cenicriviroc
Cat. No.
A13643
CAS
497223-25-3
CCR2/CCR5 inhibitor
Cenicriviroc is an experimental drug candidate for the treatment of HIV infection.Cenicriviroc is an inhibitor of CCR2 and CCR5 receptors, allowing it to function as an entry inhibitor which prevents the virus from entering into a human cell.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 497223-25-3 |
| Applications | CCR2/CCR5 inhibitor |
| Formula | C41H52N4O4S |
| Molecular Weight | 696.94 |
| Synonyms | TAK-652; TBR-652 |
| SMILES | CCCCOCCOC1=CC=C(C=C1)C2=CC/3=C(C=C2)N(CCC/C(=C3)/C(=O)NC4=CC=C(C=C4)[S@@](=O)CC5=CN=CN5CCC)CC(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 94 mg/mL (134.87 mM) |
| Water | Insoluble |
| Ethanol | 94 mg/mL (134.87 mM) |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.