CHIR-124

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CHK Inhibitor

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Catalog No. A11046

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
CHIR-124 5mg A11046-5

Regular Price: $70.00

Special Price: $56.00

CHIR-124 10mg A11046-10

Regular Price: $120.00

Special Price: $96.00

CHIR-124 25mg A11046-25

Regular Price: $220.00

Special Price: $176.00

CHIR-124 100mg A11046-100

Regular Price: $620.00

Special Price: $496.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

CHIR-124 is a novel and potent Chk1 inhibitor (IC50: 0.32 nM and 697 nM for Chk1 and Chk2 respectively).

CHIR-124

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Chemical Information

Catalog Num A11046
Actions Inhibitor
M. Wt 419.9
Formula C23H22ClN5O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 405168-58-3
Synonyms CHIR124
SMILES code C1CN2CCC1[C@@H](C2)NC3=C4C=C(C=CC4=NC(=O)C3=C5NC6=CC=CC=C6N5)Cl
Chemical Name (S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one

Biological Activity

Description
CHIR-124 is a novel and potent Chk1 inhibitor (IC50: 0.32 nM and 697 nM for Chk1 and Chk2 respectively).
Targets
Target Value
Chk1IC50: 0.3nM
FLT3IC50: 5.8nM
PDGFRIC50: 6.6nM
GSK-3IC50: 23.3nM
FynIC50: 98.8nM
PKAIC50: 103.1nM
PKCγIC50: 110nM
LCKIC50: 158.3nM
CDK2/CyclinAIC50: 191.1nM
VEGFR1/FLT1IC50: 463.6nM
Cdc2/CyclinBIC50: 505.7nM
VEGFR2/Flk1IC50: 577.9nM
PKCβ2IC50: 580nM
PKCαIC50: 580nM
Chk2IC50: 697.4nM
FGFR3IC50: 1.29μM
bFGFRIC50: 2.04μM
CDK4/CyclinDIC50: 2.05μM
PKAβ1IC50: 2.25μM
c-MetIC50: >3μM
ERK2IC50: 4.31μM
CABLIC50: 14.88μM

Solubility

Solubility (25°C) * In vitro DMSO 7 mg/mL (16.67 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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