Cobicistat (GS-9350)

Catalog No.: A11277
CYP3A Inhibitor
Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate.
Grouped product items
Product Name Price Stock Qty
Cobicistat 2mg
$80.00
In stock
Cobicistat 5mg
$100.00
In stock
Cobicistat 10mg
$135.00
In stock
Cobicistat 25mg
$250.00
In stock
Cobicistat(GS-9350) 10mM * 1mL in DMSO
$120.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Biological Activity
Discription Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate.
Targets
Target Value
Product Information
Catalog Num A11277
Formula C40H53N7O5S2
Molecular Weight 766
CAS Number 1004316-88-4
SMILES CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5
Synonyms GS9350
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 85 mg/mL (109.53 mM)
Water Insoluble
Ethanol 85 mg/mL (109.53 mM)
In vivo 5% DMSO+40% PEG 300+ddH2O 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.05 mL 65.27 mL 130.55 mL
0.5 mM 2.61 mL 13.05 mL 26.11 mL
1 mM 1.31 mL 6.53 mL 13.05 mL
5 mM 0.26 mL 1.31 mL 2.61 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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