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| Description | Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate. | ||
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| Catalog Num | A11277 |
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| Formula | C40H53N7O5S2 |
| Molecular Weight | 766 |
| CAS Number | 1004316-88-4 |
| SMILES | CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5 |
| Synonyms | GS9350 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| In vitro (25°C) | DMSO | 85 mg/mL (109.53 mM) | |
| Water | Insoluble | ||
| Ethanol | 85 mg/mL (109.53 mM) | ||
| In vivo | 5% DMSO+40% PEG 300+ddH2O | 9 mg/mL | |
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 13.05 mL | 65.27 mL | 130.55 mL |
| 0.5 mM | 2.61 mL | 13.05 mL | 26.11 mL |
| 1 mM | 1.31 mL | 6.53 mL | 13.05 mL |
| 5 mM | 0.26 mL | 1.31 mL | 2.61 mL |
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
