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Fig. 1 · Structure
Cat. No.
A12034
CAS No.
4547-24-4
Formula
C30H48O4
Mol. Weight
472.7

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Corosolic acid

Cat. No. A12034 CAS 4547-24-4
Corosolic acid is a pentacyclic triterpene acid, found in Lagerstroemia speciosa, used in dietary supplements as a glucose-lowering agent and insulin mimetic.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
A549 GI50 > 100 μM Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay [PMID: 32345458]
BV-2 IC50 47.1 μM Anti-inflammatory in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production pre-incubated before LPS challenge for 24 hrs by Griess reagent based assay [PMID: 28358502]
CCRF-CEM IC50 3.27 μM Cytotoxicity against human CEM cells after 48 hrs [PMID: 20873721]
H9 EC50 4 μg/mL Cytotoxicity against mock-infected human H9 cells after 4 days [PMID: 9748372]
H9 IC50 8 μg/mL Antiviral activity against HIV1 3B in human H9 cells after 4 days by p24 antigen ELISA [PMID: 9748372]
HCT-116 GI50 > 100 μM Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay [PMID: 32345458]
HEK293 IC50 0.81 μM Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells assessed as reduction of cortisone to cortisol conversion by scintillation counting [PMID: 20100662]
HepG2 IC50 > 10 μM Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay [PMID: 27797185]
HT-29 IC50 > 10 μM Cytotoxicity against human HT-29 cells after 48 hrs [PMID: 20873721]
MCF7 IC50 > 10 μM Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay [PMID: 27797185]
MCF7 IC50 > 10 μM Cytotoxicity against human MCF7 cells after 48 hrs [PMID: 20873721]
MCF7 GI50 18.5 μM Cytotoxicity in human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay [PMID: 28754470]
MCF7 GI50 62 μM Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay [PMID: 32345458]
MDA-MB-231 GI50 15.3 μM Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay [PMID: 28754470]
NCI-H460 IC50 > 10 μM Cytotoxicity against human NCI-H460 cells after 48 hrs [PMID: 20873721]
NCI-N87 IC50 4.4 μM Cytotoxicity against human NCI-N87 cells after 72 hrs by MTT assay [PMID: 27797185]
Sf21 IC50 > 40 μM Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis [PMID: 31774676]
SK-OV-3 IC50 10.51 μM Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay [PMID: 35500202]
SK-OV-3 IC50 26.42 μM Reversal of platinum resistance in cisplatin-resistant human SK-OV-3 cells assessed as reduction in cisplatin IC50 after 48 hrs in presence of cisplatin by SRB assay (Rvb = 28.23 microM) [PMID: 35500202]

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Specifications

Manufacturer Adooq Bioscience
CAS Number 4547-24-4
Formula C30H48O4
Molecular Weight 472.7
SMILES
C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(C[C@H]([C@@H](C5(C)C)O)O)C)C)[C@@H]2[C@H]1C)C)C(=O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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