Cellular Effect
| Cell Line | Activity | Value | Description | Reference |
|---|---|---|---|---|
| HepG2 | IC50 | 0.84 μM | Inhibition of fatty acid synthesis in human HepG2 cells after 48 hrs | [PMID: 19853443] |
Fig. 1 · Structure
Documents & Downloads
CP-640186
Cat. No.
A13134
CAS
591778-68-6
acetyl-CoA carboxylase inhibitor
CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with improved metabolic stability vs CP-610431.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 591778-68-6 |
| Applications | acetyl-CoA carboxylase inhibitor |
| Formula | C30H35N3O3 |
| Molecular Weight | 485.62 |
| SMILES | C1C[C@H](CN(C1)C2CCN(CC2)C(=O)C3=C4C=CC=CC4=CC5=CC=CC=C53)C(=O)N6CCOCC6 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 91 mg/mL (187.38 mM) |
| Water | Insoluble |
| Ethanol | 91 mg/mL (187.38 mM) |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.