Target & Activity
| Target | Activity | Value |
|---|---|---|
| hCB1 | Ki | 0.7 nM |
| rCB1 | Ki | 2.8 nM |
| hCB2 | Ki | 7.663 μM |
Fig. 1 · Structure
Documents & Downloads
CP 945598 HCl (Otenabant HCl)
Cat. No.
A11942
CAS
686347-12-6
CB1 antagonist
CP 945598 is a potent and highly selective CB1 antagonist.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 686347-12-6 |
| Applications | CB1 antagonist |
| Formula | C25H25Cl2N7O.HCl |
| Molecular Weight | 546.9 |
| Synonyms | CP-945598; Otenabant; CP-945,598 |
| SMILES | CCNC1(CCN(CC1)C2=NC=NC3=C2N=C(N3C4=CC=C(C=C4)Cl)C5=CC=CC=C5Cl)C(=O)N.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | Warmed: 5 mg/mL (9.14 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
In Vivo Preparation
- Concentration
- 16 mg/mL
- Vehicle
- 0.5% methylcellulose
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.