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Fig. 1 · Structure
Cat. No.
A15054
CAS No.
199986-75-9
Formula
C20H28N6O3
Mol. Weight
400.47

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CVT-313

Cat. No. A15054 CAS 199986-75-9

CDK2 Inhibitor

CVT-313 is a potent, selective, reversible, and ATP-competitive inhibitor of CDK2 (IC50 = 0.5 uM for Cdk2/A and Cdk2/E; 4.2 uM for Cdk1/B; 215 uM for Cdk4/D1).

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Biological Activity

Target & Activity

Target Activity Value
cdk2/cyclin A IC50 0.5 μM
Cdk1/cyclin B IC50 4.2 μM
Cdk4/cyclin D1 IC50 215 μM

Cellular Effect

Cell Line Activity Value Description Reference
Sf9 IC50 > 20 μM Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay [PMID: 30234987]
Sf9 IC50 0.176 μM Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay [PMID: 30234987]
Sf9 IC50 0.419 μM Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay [PMID: 30234987]
Sf9 IC50 2.3 μM Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay [PMID: 30234987]
Sf9 IC50 3.7 μM Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay [PMID: 30234987]
Sf9 IC50 9.2 μM Inhibition of GST-tagged CDK7/cyclinH/MAT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay [PMID: 30234987]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 199986-75-9
Applications CDK2 Inhibitor
Formula C20H28N6O3
Molecular Weight 400.47
Synonyms NG 26
SMILES
CC(C)N1C=NC2=C1N=C(N=C2NCC3=CC=C(C=C3)OC)N(CCO)CCO

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 73 mg/mL (182.28 mM)
Water Insoluble
Ethanol 73 mg/mL (182.28 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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