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Fig. 1 · Structure
Cat. No.
A11409
CAS No.
427-51-0
Formula
C24H29ClO4
Mol. Weight
416.9

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Cyproterone acetate

Cat. No. A11409 CAS 427-51-0

Androgen Receptor antagonist

Cyproterone acetate is a synthetic derivative of 17-hydroxyprogesterone, and acts as an androgen receptor antagonist as well as a weak progesterone receptor agonist with weak progestational and glucocorticoid activity.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
DU-145 IC50 50.7 μM Antiproliferative activity against androgen-insensitive human DU-145 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay [PMID: 33933755]
LNCaP IC50 43 μM Cytotoxicity against human LNCAP cells expressing androgen receptor after 72 hrs by MTT assay [PMID: 23665800]
LNCaP IC50 43 μM Cytotoxicity against human androgen receptor positive LNCAP cells after 72 hrs by MTT assay [PMID: 20226660]
LNCaP IC50 59.6 μM Antiproliferative activity against androgen-sensitive human LNCaP cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay [PMID: 33933755]
PC-3 IC50 32.3 μM Cytotoxicity against androgen receptor deficient human PC3 cells after 72 hrs by MTT assay [PMID: 23665800]
PC-3 IC50 32.3 μM Cytotoxicity against human androgen receptor negative PC3 cells after 72 hrs by MTT assay [PMID: 20226660]
PC-3 IC50 56.9 μM Antiproliferative activity against androgen-insensitive human PC-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay [PMID: 33933755]

Specifications

Manufacturer Adooq Bioscience
Actions Antagonist
CAS Number 427-51-0
Applications Androgen Receptor antagonist
Formula C24H29ClO4
Molecular Weight 416.9
SMILES
CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C=C(C4=CC(=O)[C@@H]5C[C@@H]5[C@]34C)Cl)C)OC(=O)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 72 mg/mL (172.68 mM)
Water Insoluble
Ethanol 9 mg/mL (21.58 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

In Vivo Preparation

Concentration
19 mg/mL
Vehicle
1% DMSO+30% polyethylene glycol+1% Tween 80

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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