Droxinostat

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HDAC inhibitor

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Catalog No. A10337

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Droxinostat 5mg A10337-5

Regular Price: $40.00

Special Price: $34.00

Droxinostat 10mg A10337-10

Regular Price: $70.00

Special Price: $59.50

Droxinostat 50mg A10337-50

Regular Price: $320.00

Special Price: $272.00

Droxinostat 100mg A10337-100

Regular Price: $580.00

Special Price: $493.00

Droxinostat 10mM * 1mL in DMSO A10337-10mM-D

Regular Price: $78.00

Special Price: $66.30

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8 that shows comparable inhibition of HDAC6 and HDAC8 with IC50 = 2.47 and 1.46 μmol/L, respectively.

Droxinostat

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Chemical Information

Catalog Num A10337
Actions Inhibitor
M. Wt 243.7
Formula C11H14ClNO3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 99873-43-5
Synonyms N/A
SMILES code CC1=C(C=CC(=C1)Cl)OCCCC(=O)NO
Chemical Name 4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide

Biological Activity

Description
Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8 that shows comparable inhibition of HDAC6 and HDAC8 with IC50 = 2.47 and 1.46 μmol/L, respectively.
Targets
Target Value
HDAC8IC50: 1.46μM
HDAC6IC50: 2.47μM
HDAC3IC50: 16.9μM
HDAC9IC50: >20μM
HDAC10IC50: >20μM
HDAC1IC50: >20μM
HDAC2IC50: >20μM
HDAC4IC50: >20μM
HDAC5IC50: >20μM
HDAC7IC50: >20μM

Solubility

Solubility (25°C) * In vitro DMSO 49 mg/mL (201.07 mM)
Water <1 mg/mL (<1 mM)
Ethanol 49 mg/mL (201.07 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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