Echinomycin

HIF-1α inhibitor

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Catalog No. A14021

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Echinomycin 5mg A14021-5
$220.00
Echinomycin 10mg A14021-10
$400.00
Echinomycin 25mg A14021-25
$900.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in glycolysis, angiogenesis, migration, and invasion. Echinomycin is a cell-permeable inhibitor of HIF-1-mediated gene transcription

Echinomycin

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Chemical Information

Catalog Num A14021
Actions Inhibitor
M. Wt 1101.3
Formula C51H64N12O12S2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 512-64-1
Synonyms Antibiotic A 654I, NSC 526417, Quinomycin A, SK 302B, NSC 13502
SMILES code CC1C(=O)N(C2CSC(C(C(=O)N(C(C(=O)OC[[email protected]](C(=O)N1)NC(=O)C3=NC4=CC=CC=C4N=C3)C(C)C)C)N(C(=O)C(NC(=O)[[email protected]@H](COC(=O)C(N(C2=O)C)C(C)C)NC(=O)C5=NC6=CC=CC=C6N=C5)C)C)SC)C
Chemical Name N-(2-quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-(8??1)-lactone,cyclic (3??7)-thioether-L-valine

Biological Activity

Description
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in glycolysis, angiogenesis, migration, and invasion. Echinomycin is a cell-permeable inhibitor of HIF-1-mediated gene transcription

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