Entrectinib

TRK, ROS1, ALK inhibitor

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Catalog No. A15801

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Entrectinib 10mg A15801-10
$120.00
Entrectinib 25mg A15801-25
$265.00
Entrectinib 5mg A15801-5
$75.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity.

Entrectinib

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Chemical Information

Catalog Num A15801
Actions Inhibitor
M. Wt 560.64
Formula C31H34F2N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1108743-60-7
Synonyms RXDX-101, RXDX-101, RXDX-101, NMS E628, NMS-E628, NMSE628
SMILES code CN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6
Chemical Name (Z)-N-(5-(3,5-difluorobenzyl)-1H-indazol-3(2H)-ylidene)-4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide

Biological Activity

Description
Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity.
Targets
TrkA TrkB TrkC ROS1 ALK

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