EPZ-5676

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DOT1L Inhibitor‎

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Catalog No. A12735

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
EPZ-5676 5mg A12735-5

Regular Price: $80.00

Special Price: $64.00

EPZ-5676 10mg A12735-10

Regular Price: $150.00

Special Price: $120.00

EPZ-5676 25mg A12735-25

Regular Price: $300.00

Special Price: $240.00

EPZ-5676 50mg A12735-50

Regular Price: $500.00

Special Price: $400.00

EPZ-5676 10mM * 1mL in DMSO A12735-10mM-D

Regular Price: $149.00

Special Price: $119.20

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

EPZ-5676 is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity.

EPZ-5676

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Chemical Information

Catalog Num A12735
Actions Inhibitor
M. Wt 562.7
Formula C30H42N8O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1380288-87-8
Synonyms EPZ5676, EPZ 5676
SMILES code CC(C)N(C[C@@H]1[[email protected]]([[email protected]]([C@@H](O1)N2C=NC3=C2N=CN=C3N)O)O)C4CC(C4)CCC5=NC6=C(N5)C=C(C=C6)C(C)(C)C
Chemical Name (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol

Biological Activity

Description
EPZ-5676 is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity.
Targets
DOT1L (Cell-free assay)
80 pM(Ki)

Solubility

Solubility (25°C) * In vitro DMSO 100 mg/mL (177.71 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (177.71 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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