Etoposide (VP-16)

Catalog No.: A10373
Topoisomerase II inhibitor
Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation of the DNA strands, and by doing so causes DNA strands to break. Therefore, this causes errors in DNA synthesis and promotes apoptosis of the cancer cell.
Grouped product items
Product Name Price Stock Qty
Etoposide 100mg
$50.00
In stock
Etoposide 500mg
$150.00
In stock
Etoposide (VP-16) 10mM * 1mL in DMSO
$65.00
In stock
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Important Notice: For research use only. We do not sell to patients.

Prop65 Warning  WARNING: Attention California Residents: This product can expose you to chemicals including Etoposide (VP-16) , which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov

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Adooq Products cited in reputable paper
Adooq's Etoposide (VP-16) has been cited by 6 publications
  • Bageshri Naimish Nanavati, .et al. , bioRxiv, 2023, Feb 23 PMID: 36865131
  • Sibei Wang, .et al. , Molecules, 2023, Jan 19;28(3):1016 PMID: 36770683
  • Reiko Watanabe, .et al. , J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
  • Chen JC, .et al. , Biomolecules, 2019, Sep 9;9(9) PMID: 31505885
  • Takashi Azuma, .et al. , SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
  • Calhelha RC, .et al. , Analyst, 2017, Oct 23;142(21):4124-4141 PMID: 28991301
  • Biological Activity
    Discription Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation of the DNA strands, and by doing so causes DNA strands to break. Therefore, this causes errors in DNA synthesis and promotes apoptosis of the cancer cell.
    Targets
    Target Value
    Product Information
    Catalog Num A10373
    Formula C29H32O13
    Molecular Weight 588.6
    CAS Number 33419-42-0
    SMILES C[C@@H]1OC[C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O
    Synonyms Vepesid
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 99 mg/mL (168.2 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 5% DMSO+40% PEG 300+5% Tween 80+ddH2O 14 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 16.99 mL 84.95 mL 169.89 mL
    0.5 mM 3.4 mL 16.99 mL 33.98 mL
    1 mM 1.7 mL 8.49 mL 16.99 mL
    5 mM 0.34 mL 1.7 mL 3.4 mL
    Useful Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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