Filgotinib

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JAK inhibitor

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Catalog No. A14232

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Filgotinib 10mg A14232-10

Regular Price: $110.00

Special Price: $93.50

Filgotinib 25mg A14232-25

Regular Price: $180.00

Special Price: $153.00

Filgotinib 50mg A14232-50

Regular Price: $280.00

Special Price: $238.00

Filgotinib 10mM * 1mL in DMSO A14232-10mM-D

Regular Price: $75.00

Special Price: $63.75

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Filgotinib is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.

Filgotinib

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Chemical Information

Catalog Num A14232
Actions Inhibitor
M. Wt 425.5
Formula C21H23N5O3S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1206161-97-8
Synonyms GLPG0634
SMILES code C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5
Chemical Name N-[5-[4-[(1,1-Dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide

Biological Activity

Description
Filgotinib is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
Targets
JAK1 JAK2 TYK2 JAK3
10 nM28 nM116 nM810 nM

Solubility

Solubility (25°C)* In vitro DMSO 85 mg/mL (199.76 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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