FK-506 (Tacrolimus)

FK-506 is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It reduces interleukin-2 (IL-2) production by T-cells.
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Product Name Price Stock Qty
FK-506 50mg
$55.00
In stock
FK-506 100mg
$100.00
In stock
FK-506 500mg
$250.00
In stock
FK-506 10mM * 1mL in DMSO
$68.00
In stock
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Adooq Products cited in reputable paper
Adooq's FK-506 (Tacrolimus) has been cited by 2 publications
  • Ogawa Y, .et al. , Neurobiol Dis, 2018, Oct;118:142-154 PMID: 30026035
  • Yuko Okamoto, .et al. , J Drug Deliv Sci Technol, 2018, 47: 62-66
  • Biological Activity
    Discription FK-506 is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It reduces interleukin-2 (IL-2) production by T-cells.
    Targets
    Target Value
    Product Information
    Catalog Num A10389
    Formula C44H69NO12
    Molecular Weight 804
    CAS Number 104987-11-3
    SMILES C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC
    Synonyms Fujimycin, Prograf , Tacrolimus
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 81 mg/mL (100.74 mM)
    Water Insoluble
    Ethanol 71 mg/mL (88.31 mM)
    In vivo 5% DMSO+corn oil 14 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 12.44 mL 62.19 mL 124.38 mL
    0.5 mM 2.49 mL 12.44 mL 24.88 mL
    1 mM 1.24 mL 6.22 mL 12.44 mL
    5 mM 0.25 mL 1.24 mL 2.49 mL
    Useful Calculator

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