FK-506

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mTOR inhibitor

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Catalog No. A10389

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
FK-506 50mg A10389-50

Regular Price: $55.00

Special Price: $46.75

FK-506 100mg A10389-100

Regular Price: $100.00

Special Price: $85.00

FK-506 500mg A10389-500

Regular Price: $250.00

Special Price: $212.50

FK-506 10mM * 1mL in DMSO A10389-10mM-D

Regular Price: $68.00

Special Price: $57.80

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

FK-506 is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It reduces interleukin-2 (IL-2) production by T-cells.

FK-506

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Chemical Information

Catalog Num A10389
Actions Inhibitor
M. Wt 804
Formula C44H69NO12
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 104987-11-3
Synonyms FK506, Fujimycin, Prograf , Tacrolimus
SMILES code C[[email protected]@H]1C[[email protected]@H]([[email protected]@H]2[[email protected]](C[[email protected]]([[email protected]@](O2)(C(=O)C(=O)N3CCCC[[email protected]]3C(=O)O[[email protected]@H]([[email protected]@H]([[email protected]](CC(=O)[[email protected]@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[[email protected]@H]4CC[[email protected]]([[email protected]@H](C4)OC)O)/C)O)C)OC)OC
Chemical Name N/A

Biological Activity

Description
FK-506 is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It reduces interleukin-2 (IL-2) production by T-cells.
Targets
FKBP12 (T cells)

Solubility

Solubility (25°C)* In vitro DMSO 94 mg/mL (116.91 mM)
Water <1 mg/mL (<1 mM)
Ethanol 83 mg/mL (103.23 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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