GDC-0152

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IAP antagonist

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Catalog No. A14135

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GDC-0152 10mg A14135-10

Regular Price: $150.00

Special Price: $120.00

GDC-0152 25mg A14135-25

Regular Price: $300.00

Special Price: $240.00

GDC-0152 50mg A14135-50

Regular Price: $500.00

Special Price: $400.00

GDC-0152 10mM * 1mL in DMSO A14135-10mM-D

Regular Price: $135.00

Special Price: $108.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity.

GDC-0152

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Chemical Information

Catalog Num A14135
Actions Antagonist
M. Wt 498.64
Formula C25H34N6O3S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 873652-48-3
Synonyms GDC0152, GDC 0152
SMILES code CC(C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC3=C(N=NS3)C4=CC=CC=C4)NC
Chemical Name (S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-(4-phenyl-1,2,3-thiadiazol-5-yl)pyrrolidine-2-carboxamide

Biological Activity

Description
GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity.
Targets
Target Value
MLXBIR3SGki: 14nM
cIAP1-BIR3ki: 17nM
XIAP-BIR3ki: 28nM
cIAP2-BIR3ki: 43nM
XIAP-BIR2ki: 112nM
cIAP2-BIR2ki: 9.6μM
cIAP1-BIR2ki: 14.5μM

Solubility

Solubility (25°C) * In vitro DMSO 99 mg/mL (198.54 mM)
Water 3 mg/mL (6.01 mM)
Ethanol 99 mg/mL (198.54 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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