GDC0994 (Ravoxertinib)

Catalog No.: A13420
ERK1/2 inhibitor
GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways.
Grouped product items
Product Name Price Stock Qty
GDC0994 5mg
$80.00
In stock
GDC0994 10mg
$100.00
In stock
GDC0994 25mg
$190.00
In stock
GDC0994 10mM * 1mL in DMSO
$85.00
In stock
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Biological Activity
Discription GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways.
Targets
Target Value
Product Information
Catalog Num A13420
Formula C21H18ClFN6O2
Molecular Weight 440.87
CAS Number 1453848-26-4
SMILES CN1C(=CC=N1)NC2=NC=CC(=N2)C3=CC(=O)N(C=C3)[C@H](CO)C4=CC(=C(C=C4)Cl)F
Synonyms GDC-0994
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 83 mg/mL (188.7 mM)
Water Insoluble
Ethanol 83 mg/mL
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.68 mL 113.41 mL 226.82 mL
0.5 mM 4.54 mL 22.68 mL 45.36 mL
1 mM 2.27 mL 11.34 mL 22.68 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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