GDC0994

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ERK1/2 inhibitor

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Catalog No. A13420

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GDC0994 5mg A13420-5
$80.00
GDC0994 10mg A13420-10
$100.00
GDC0994 25mg A13420-25
$190.00
GDC0994 10mM * 1mL in DMSO A13420-10mM-D
$85.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways.

GDC0994

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Chemical Information

Catalog Num A13420
Actions Inhibitor
M. Wt 440.87
Formula C21H18ClFN6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1453848-26-4
Synonyms GDC-0994
SMILES code CN1C(=CC=N1)NC2=NC=CC(=N2)C3=CC(=O)N(C=C3)[[email protected]](CO)C4=CC(=C(C=C4)Cl)F
Chemical Name (S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-(1-methyl-1H-pyrazol-5-ylamino)pyrimidin-4-yl)pyridin-2(1H)-one

Biological Activity

Description
GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways.
Targets
ERK2 ERK1
0.3 nM1.1 nM

Solubility

Solubility (25°C)* In vitro DMSO 88 mg/mL (200.06 mM)
Water <1 mg/mL (<1 mM)
Ethanol 88 mg/mL (200.06 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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